Tay-Sachs disease specific cell type
Tay-Sachs disease is a lysosomal disease (lipidosis) in which hexosaminidase A, an enzyme that degrades ganglioside GM2, is absent. A hereditary disease that affects young children almost exclusively of eastern European Jewish descent, in which an enzyme deficiency leads to the accumulation of gangliosides in the brain and nerve tissue, resulting in mental retardation, convulsions, blindness, and, ultimately, death.
The Dictionary of Cell and Molecular Biology:Third Edition
The American Heritage Dictionary of the English Language:Fourth Edition. 2000.
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