loading...| Preferred Name |
primitive knot |
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| Synonyms |
Spemann Mangold organizer primitive node embryonic organizer Hensen node Hensen's node embryo organizer embryonic shield Spemann's organizer organizer shield node Henson's node dorsal marginal zone nodus primitivus DMZ |
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| Definitions |
Organizer for gastrulation in vertebrates. The primitive knot starts as a regional knot of cells that forms on the blastodisc immediately anterior to where the outer layer of cells will begin to migrate inwards - an area known as the primitive streak. Posterior to the node is the primitive pit, where the cells of the epiblast (the upper layer of embryonic cells) initially begin to invaginate. This invagination expands posteriorly into the primitive groove as the cells layers continue to move into the space between the embryonic cells and the yolk. This differentiates the embryo into the germ layers - endoderm, mesoderm, and ectoderm. The primitive knot migrates posteriorly as gastrulation proceeds, eventually being absorbed into the tail bud.[WP]. the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo[MP]. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0003062 |
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| contributes to morphology of | ||
| database_cross_reference |
BTO:0003395 XAO:0000072 EHDAA2:0001272 UMLS:C1283999 SCTID:361464001 TAO:0000071 VHOG:0000598 EMAPA:16075 AAO:0000346 NCIT:C34266 Wikipedia:Regional_specification#Dorsal.2Fventral_axis_.26_organizer BILA:0000053 ZFA:0000071 MESH:D020897 EHDAA:549 FMA:293116 GAID:1312 |
|
| definition |
Organizer for gastrulation in vertebrates. The primitive knot starts as a regional knot of cells that forms on the blastodisc immediately anterior to where the outer layer of cells will begin to migrate inwards - an area known as the primitive streak. Posterior to the node is the primitive pit, where the cells of the epiblast (the upper layer of embryonic cells) initially begin to invaginate. This invagination expands posteriorly into the primitive groove as the cells layers continue to move into the space between the embryonic cells and the yolk. This differentiates the embryo into the germ layers - endoderm, mesoderm, and ectoderm. The primitive knot migrates posteriorly as gastrulation proceeds, eventually being absorbed into the tail bud.[WP]. the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo[MP]. |
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| develops_from | ||
| editor note |
This class groups together possibly disparate structures, following homology class in vHOG; early development terms need review |
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| external_definition |
A signaling center that directs the development of the whole embryo or of part of the embryo.[AAO] Embryonic structure that is a local accumulation of cells along the germ ring. The shield marks the dorsal side of the embryo[ZFIN:ZDB-PUB-961014-576]. |
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| has_alternative_id |
UBERON:0004018 |
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| has_broad_synonym |
node |
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| has_exact_synonym |
Spemann Mangold organizer primitive node embryonic organizer Hensen node Hensen's node embryo organizer embryonic shield Spemann's organizer organizer shield |
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| has_obo_namespace |
uberon |
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| has_related_synonym |
Henson's node dorsal marginal zone nodus primitivus DMZ |
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| homology_notes |
The organizer is a central feature of vertebrate embryogenesis. It was first characterized in functional terms in amphibians by Spemann and Mangold (1924), and homologous tissues have since been identified in representatives of most other vertebrate classes, including mammals (the node), birds (Henson's node) and teleost fish (the embryonic shield).[well established][VHOG] |
|
| id |
UBERON:0003062 |
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| immediate transformation of | ||
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#pheno_slim http://purl.obolibrary.org/obo/uberon/core#early_development |
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| label |
primitive knot |
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| notation |
UBERON:0003062 |
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| only in taxon | ||
| part_of | ||
| prefLabel |
primitive knot |
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| treeView |
http://purl.obolibrary.org/obo/UBERON_0004341 |
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| subClassOf |