OoEVV tract tracing experiments
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Description: This serves as an instantiation of the OoEVV ontology design pattern for variables derived from models of neuroanatomical tract-tracing experiments described in detail in Russ et al. 2011 (http://www.biomedcentral.com/1471-2105/12/351). This serves as a well-developed example system for development of the KEfED formulation.
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Definition: This is an unconventional use of the 'view' functionality of BioPortal. Rather than filtering the existing full ontology for a selection of terms within the larger whole (since OoEVV is an ontology design pattern rather than a complete ontology), we use views to instantiate the design pattern within specific domains.
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Ontology ID: 2108
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Definition Language: Manual
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Created By:
Gully Burns, gully@usc.edu
OoEVV vaccine protection experiments
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Description: This serves as an instantiation of the OoEVV ontology design pattern for variables derived from vaccine protection studies that have been previously indexed in the Los Alamos National Laboratories (LANL) HIV Vaccine Trials Database. This is a comprehensive index of research outcomes derived from vaccine studies in nonhuman primates and provides an excellent index of papers for examination with our approach.
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Definition: This is an unconventional use of the 'view' functionality of BioPortal. Rather than filtering the existing full ontology for a selection of terms within the larger whole (since OoEVV is an ontology design pattern rather than a complete ontology), we use views to instantiate the design pattern within specific domains.
This view is manually curated OoEVV variables and scales from the following papers:
I. M. Belyakov et al., (2001) “Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of ma- caques” Nature medicine, 7(12):1320-6.
S. Buge et al., (2003) “Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge” AIDS Res Hum Retroviruses, 19(10): 891-900.
A. Cafaro et al., (2001) “Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P),” Vaccine 19:2862-77.
D. Fuller et al. (2002) “Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine” J Virol 76(7): 3309-17.
V. Gomez-Roman et al. (2006) “Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques” Vaccine, 24(23): 5064-72.
W. Lun et al. (2004) “Loss of virus-specific CD4(+) T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques” J Gen Virol., 85(7): 1955-63.
K. Muthumani et al. (2003) “Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in Rhesus Macaques.” Vaccine 21(7-8): 629-37.
M. Rosati et al. (2005) “DNA vaccines expressing different forms of sim- ian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge” J Virol 79(13): 8480-92.
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Ontology ID: 2109
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Definition Language: Manual
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Created By:
Gully Burns, gully@usc.edu