Toll-Like Receptor 3

TLR3

Toll-Like Receptor 3

Toll-Like_Receptor-3

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Toll-Like_Receptor-3

C30104

NCIExpressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes by human TLR3 Gene (TLR Family), 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3 contains a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI)

Toll-Like Receptor 3PTNCI

TLR3SYNCI

7098

CL320234

603029

'Cell Surface Receptor' and (Gene_Product_Has_Biochemical_Function some Receptor) and (Gene_Product_Encoded_By_Gene some 'TLR3 Gene') and (Gene_Product_Plays_Role_In_Biological_Process some 'RNA Binding') and (Gene_Product_Plays_Role_In_Biological_Process some 'Receptor Signaling') and (Gene_Product_Plays_Role_In_Biological_Process some 'Immune Response') and (Gene_Product_Is_Element_In_Pathway some 'Toll-Like Receptor Pathway')

Toll-Like Receptor 3

Toll-Like Receptor 3

Receptor

O15455

TLR3

Toll-Like Receptor 3