NCI Thesaurus - Sevoflurane - Terms | NCBO BioPortal

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Preferred Name (Preferred_Name)	Sevoflurane
Synonyms (Synonym)	1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- SEVOFLURANE Sevoflurane Ultane
ID	Sevoflurane
Full Id	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Sevoflurane
Cas Registry	28523-86-6
Code	C47717
Concept In Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Contributing Source	FDA
Definition	NCIA fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate.
Fda Unii Code	38LVP0K73A
Full Syn	SevofluranePTNCI UltaneBRNCI SEVOFLURANEPTFDA38LVP0K73A Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-SNNCI 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propaneSNNCI
Has Salt Form	Sibutramine Hydrochloride
Preferred Name	Sevoflurane
Label	Sevoflurane
Semantic Type	Pharmacologic Substance
Synonym	Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Ultane SEVOFLURANE Sevoflurane
Umls Cui	C0074414
Sub Class Of	Anesthetic Agent

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Mapping To	Source	Comment	Relationship Type	Mapped By	Mapped On	Notes
sevoflurane (Chemical entities of biological interest)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
Sevoflurane (Galen)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
sevoflurane (Experimental Factor Ontology)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
sevoflurane (Physician Data Query)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
sevoflurane (Medical Subject Headings)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
sevoflurane (National Drug File)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes
SEVOFLURANE (National Drug File)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes

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