NCI Thesaurus - Interferon Gamma Receptor Alpha Chain - Terms | NCBO BioPortal

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Preferred Name (Preferred_Name)	Interferon Gamma Receptor Alpha Chain
Synonyms (Synonym)	CD119 CD119 Antigen CDw119 IFN-Gamma-R1 Immune Interferon Receptor Interferon Gamma Receptor Alpha Chain Interferon Gamma Receptor-1
ID	Interferon_Gamma_Receptor_Alpha_Chain
Full Id	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Interferon_Gamma_Receptor_Alpha_Chain
Code	C37286
Definition	NCIExpressed in monocytes, lymphocytes, and placenta by human IFNGR1 Gene (Type II Cytokine Receptor Family), monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain is a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI)
Design Note	Protein_Plays_Role_In_Biological_Process: Macrophage Activation
Full Syn	Interferon Gamma Receptor-1SYNCI Interferon Gamma Receptor Alpha ChainPTNCI CDw119SYNCI Immune Interferon ReceptorSYNCI IFN-Gamma-R1SYNCI CD119SYNCI CD119 AntigenSYNCI
Locus	3459
Nci Meta Cui	CL321782
Omim Number	107470
Equivalent Class	'Cytokine Receptor' and (Gene_Product_Has_Biochemical_Function some 'Cell Surface Receptor') and (Gene_Product_Is_Physical_Part_Of some 'Interferon Gamma Receptor Complex') and (Gene_Product_Encoded_By_Gene some 'IFNGR1 Gene') and (Gene_Product_Plays_Role_In_Biological_Process some 'Antiviral Response') and (Gene_Product_Plays_Role_In_Biological_Process some 'Receptor Signaling') and (Gene_Product_Is_Element_In_Pathway some 'Interferon Signaling Modulation Pathway') and (Gene_Product_Is_Element_In_Pathway some 'T-Cell Polarization Pathway') and (Gene_Product_Is_Element_In_Pathway some 'IFN Gamma Signaling Pathway') and (Gene_Product_Is_Element_In_Pathway some 'Th1/Th2 Differentiation Pathway')
Preferred Name	Interferon Gamma Receptor Alpha Chain
Label	Interferon Gamma Receptor Alpha Chain
Semantic Type	Receptor
Swiss Prot	P15260
Synonym	Immune Interferon Receptor CD119 CD119 Antigen Interferon Gamma Receptor-1 IFN-Gamma-R1 CDw119 Interferon Gamma Receptor Alpha Chain

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Mapping To	Source	Comment	Relationship Type	Mapped By	Mapped On	Notes
INTERFERON, GAMMA, RECEPTOR 1 (Online Mendelian Inheritance in Man)	LOOM		skos:closeMatch	amirg	05/17/10	View Notes

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