National Drug File - Prions [Chemical/Ingredient] | NCBO BioPortal

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Preferred Name	Prions [Chemical/Ingredient]
Synonyms	Prion Proteins Prions PrP Proteins
ID	N0000169116
Full Id	http://purl.bioontology.org/ontology/NDFRT/N0000169116
CHD	Proteins [Chemical/Ingredient]
MESH_DEFINITION	Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
MESH_DUI	D011328
MESH_NAME	Prions
MESH_UI	M0017586
NDFRT_KIND	INGREDIENT_KIND
NUI	N0000169116
Semantic_Type	Amino Acid, Peptide, or Protein
SYNONYM PT	Prions
SYNONYM SY	Prion Proteins PrP Proteins
TUI	T116
UMLS_CUI	C0033164

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Mapping To	Ontology	Source	Comment	Relationship	Added By	Added On	Notes
http://bioonto.de/mesh.owl#D011328	OWL Version of MeSH	NCBO (lexical mapping)		skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/SNOMEDCT/84676004	SNOMED Clinical Terms	NLM UMLS (CUI)	CUI: C0033164	skos:closeMatch	loom	04/02/13	View Notes
http://bioonto.de/mesh.owl#D12.776.785	OWL Version of MeSH	NCBO (lexical mapping)		skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/LNC/LP19935-3	Logical Observation Identifier Names and Codes	NLM UMLS (CUI)	CUI: C0033164	skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/RCD/X79pc	Read Codes, Clinical Terms Version 3 (CTV3)	NLM UMLS (CUI)	CUI: C0033164	skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/MSH/D011328	Medical Subject Headings (MeSH)	NLM UMLS (CUI)	CUI: C0033164	skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/CSP/3100-6209	CRISP Thesaurus, 2006	NLM UMLS (CUI)	CUI: C0033164	skos:closeMatch	loom	04/02/13	View Notes
http://purl.bioontology.org/ontology/MSH/D011328	Medical Subject Headings (MeSH)	NCBO (lexical mapping)		skos:closeMatch	loom	04/02/13	View Notes

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